Limestone is a town in Aroostook County, Maine, United States. The population was 2,314 at the 2010 census.The town is best known for being the home of the Loring Commerce Centre and Maine School of Science and Math which in 2017 was ranked the #1 High School in Maine, #10 STEM School in the USA and #19 Best School in the USA.The population center of the town is in Limestone, in the east-central part of the town.